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Hematopoietic stem cell-specific GFP-expressing transgenic mice generated by genetic excision of a pan-hematopoietic rep... PDF available through Get Fulltext Research

Perez-Cunningham, Jessica Boyer, Scott W Landon, Mark Forsberg, E Camilla

Published in Experimental hematology

Selective labeling of specific cell types by expression of green fluorescent protein (GFP) within the hematopoietic system would have great utility in identifying, localizing, and tracking different cell populations in flow cytometry, microscopy, lineage tracing, and transplantation assays. In this report, we describe the generation and characteriz...

Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.

Häußler, Daniela Mangold, Martin Furtmann, Norbert Braune, Annett Blaut, Michael Bajorath, Jürgen Stirnberg, Marit Gütschow, Michael

Published in Chemistry (Weinheim an der Bergstrasse, Germany)

Matriptase-2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase-2 is considered as an attractive strategy for the treatment of iron-overload diseases, such as hemochromatosis and β-thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Fiv...

IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC. PDF available through Get Fulltext Research

Ennajdaoui, Hanane Howard, Jonathan M Sterne-Weiler, Timothy Jahanbani, Fereshteh Coyne, Doyle J Uren, Philip J Dargyte, Marija Katzman, Sol Draper, Jolene M Wallace, Andrew ...

Published in Cell reports

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cells. Using a combination of genome-wide approaches, we have identified 164 direct mRNA targets of IGF...

Facilitating a culture of responsible and effective sharing of cancer genome data.

Siu, Lillian L Lawler, Mark Haussler, David Knoppers, Bartha Maria Lewin, Jeremy Vis, Daniel J Liao, Rachel G Andre, Fabrice Banks, Ian Barrett, J Carl ...

Published in Nature medicine

Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precisi...

TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to...

Si, H Lu, H Yang, X Mattox, A Jang, M Bian, Y Sano, E Viadiu, H Yan, B Yau, C ...

Published in Oncogene

The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanCancer 12 project, reminiscent of gene programs com...

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. PDF available through Get Fulltext Research

Lee, John K Phillips, John W Smith, Bryan A Park, Jung Wook Stoyanova, Tanya McCaffrey, Erin F Baertsch, Robert Sokolov, Artem Meyerowitz, Justin G Mathis, Colleen ...

Published in Cancer cell

MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostat...

Pathway-Based Genomics Prediction using Generalized Elastic Net. PDF available through Get Fulltext Research

Sokolov, Artem Carlin, Daniel E Paull, Evan O Baertsch, Robert Stuart, Joshua M

Published in PLoS computational biology

We present a novel regularization scheme called The Generalized Elastic Net (GELnet) that incorporates gene pathway information into feature selection. The proposed formulation is applicable to a wide variety of problems in which the interpretation of predictive features using known molecular interactions is desired. The method naturally steers sol...

The actual and potential costs of meningitis surveillance in the African meningitis belt: Results from Chad and Niger.

Irurzun-Lopez, Maite Erondu, Ngozi A Djibo, Ali Griffiths, Ulla Stuart, James M Fernandez, Katya Ronveaux, Olivier Le Gargasson, Jean-Bernard Gessner, Bradford D Colombini, Anaïs ...

Published in Vaccine

The introduction of serogroup A meningococcal conjugate vaccine in the African meningitis belt required strengthened surveillance to assess long-term vaccine impact. The costs of implementing this strengthening had not been assessed. The ingredients approach was used to retrospectively determine bacterial meningitis surveillance costs in Chad and N...

A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt. PDF available through Get Fulltext Research

Manigart, Olivier Trotter, Caroline Findlow, Helen Assefa, Abraham Mihret, Wude Moti Demisse, Tesfaye Yeshitela, Biruk Osei, Isaac Hodgson, Abraham Quaye, Stephen Laryea ...

Published in PloS one

The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis b...

Response thresholds for epidemic meningitis in sub-Saharan Africa following the introduction of MenAfriVac®.

Trotter, Caroline L Cibrelus, Laurence Fernandez, Katya Lingani, Clément Ronveaux, Olivier Stuart, James M

Published in Vaccine

Since 2010, countries in the African meningitis belt have been introducing a new serogroup A meningococcal conjugate vaccine (MenAfriVac(®)) through mass campaigns. With the subsequent decline in meningitis due to Neisseria meningitidis serogroup A (NmA) and relative increase in meningitis due to other serogroups, mainly N. meningitidis serogroup W...

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