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Meningococcal Meningitis Surveillance in the African Meningitis Belt, 2004-2013.

Lingani, Clément Bergeron-Caron, Cassi Stuart, James M Fernandez, Katya Djingarey, Mamoudou H Ronveaux, Olivier Schnitzler, Johannes C Perea, William A

Published in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

An enhanced meningitis surveillance network was established across the meningitis belt of sub-Saharan Africa in 2003 to rapidly collect, disseminate, and use district weekly data on meningitis incidence. Following 10 years' experience with enhanced surveillance that included the introduction of a group A meningococcal conjugate vaccine, PsA-TT (Men...

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem... PDF available through Get Fulltext Research

Ugarte, Fernando Sousae, Rebekah Cinquin, Bertrand Martin, Eric W Krietsch, Jana Sanchez, Gabriela Inman, Margaux Tsang, Herman Warr, Matthew Passegué, Emmanuelle ...

Published in Stem cell reports

Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem...

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC. PDF available through Get Fulltext Research

Ballard, Mimmi S Zhu, Anna Iwai, Naomi Stensrud, Michael Mapps, Aurelia Postiglione, Maira Pia Knoblich, Juergen A Hinck, Lindsay

Published in Cell reports

Tissue homeostasis requires somatic stem cell maintenance; however, mechanisms regulating this process during organogenesis are not well understood. Here, we identify asymmetrically renewing basal and luminal stem cells in the mammary end bud. We demonstrate that SLIT2/ROBO1 signaling regulates the choice between self-renewing asymmetric cell divis...

Chemoprophylaxis and vaccination in preventing subsequent cases of meningococcal disease in household contacts of a case... PDF available through Get Fulltext Research

Telisinghe, L Waite, T D Gobin, M Ronveaux, O Fernandez, K Stuart, J M Scholten, R J P M

Published in Epidemiology and infection

Household contacts of an index case of invasive meningococcal disease (IMD) are at increased risk of acquiring disease. In revising WHO guidance on IMD in sub-Saharan Africa, a systematic review was undertaken to assess the effect of chemoprophylaxis and of vaccination in preventing subsequent cases of IMD in household contacts following an index c...

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerat... PDF available through Get Fulltext Research

Pietras, Eric M Reynaud, Damien Kang, Yoon-A Carlin, Daniel Calero-Nieto, Fernando J Leavitt, Andrew D Stuart, Joshua M Göttgens, Berthold Passegué, Emmanuelle

Published in Cell stem cell

Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all ...

Hematopoietic development at high altitude: blood stem cells put to the test.

Zovein, Ann C Forsberg, E Camilla

Published in Development (Cambridge, England)

In February 2015, over 200 scientists gathered for the Keystone Hematopoiesis meeting, which was held at the scenic Keystone Resort in Keystone, Colorado, USA. The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schroeder, put together an exciting program, during which field leaders and new investigators presented discoveries that spanne...

C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. PDF available through Get Fulltext Research

Hoeffel, Guillaume Chen, Jinmiao Lavin, Yonit Low, Donovan Almeida, Francisca F See, Peter Beaudin, Anna E Lum, Josephine Low, Ivy Forsberg, E Camilla ...

Published in Immunity

Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fat...

The Diversity of Meningococcal Carriage Across the African Meningitis Belt and the Impact of Vaccination With a Group A ...

Consortium, Menafricar

Published in The Journal of Infectious Diseases

Control selection methods in recent case–control studies conducted as part of infectious disease outbreaks

Waldram, Alison McKerr, Caoimhe Gobin, Maya Adak, Goutam Stuart, James M. Cleary, Paul

Published in European Journal of Epidemiology

Successful investigation of national outbreaks of communicable disease relies on rapid identification of the source. Case–control methodologies are commonly used to achieve this. We assessed control selection methods used in recently published case–control studies for methodological and resource issues to determine if a standard approach could be i...

The DREAM complex promotes gene body H2A.Z for target repression.

Latorre, Isabel Chesney, Michael A Garrigues, Jacob M Stempor, Przemyslaw Appert, Alex Francesconi, Mirko Strome, Susan Ahringer, Julie

Published in Genes & development

The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, D...

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