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Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem...

Ugarte, Fernando Sousae, Rebekah Cinquin, Bertrand Martin, Eric W Krietsch, Jana Sanchez, Gabriela Inman, Margaux Tsang, Herman Warr, Matthew Passegué, Emmanuelle ...

Published in Stem cell reports

Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that manipulation of chromatin dynamics influences stem...

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.

Ballard, Mimmi S Zhu, Anna Iwai, Naomi Stensrud, Michael Mapps, Aurelia Postiglione, Maira Pia Knoblich, Juergen A Hinck, Lindsay

Published in Cell reports

Tissue homeostasis requires somatic stem cell maintenance; however, mechanisms regulating this process during organogenesis are not well understood. Here, we identify asymmetrically renewing basal and luminal stem cells in the mammary end bud. We demonstrate that SLIT2/ROBO1 signaling regulates the choice between self-renewing asymmetric cell divis...

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerat...

Pietras, Eric M Reynaud, Damien Kang, Yoon-A Carlin, Daniel Calero-Nieto, Fernando J Leavitt, Andrew D Stuart, Joshua M Göttgens, Berthold Passegué, Emmanuelle

Published in Cell stem cell

Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all ...

Hematopoietic development at high altitude: blood stem cells put to the test.

Zovein, Ann C Forsberg, E Camilla

Published in Development (Cambridge, England)

In February 2015, over 200 scientists gathered for the Keystone Hematopoiesis meeting, which was held at the scenic Keystone Resort in Keystone, Colorado, USA. The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schroeder, put together an exciting program, during which field leaders and new investigators presented discoveries that spanne...

C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages.

Hoeffel, Guillaume Chen, Jinmiao Lavin, Yonit Low, Donovan Almeida, Francisca F See, Peter Beaudin, Anna E Lum, Josephine Low, Ivy Forsberg, E Camilla ...

Published in Immunity

Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fat...

Control selection methods in recent case–control studies conducted as part of infectious disease outbreaks

Waldram, Alison McKerr, Caoimhe Gobin, Maya Adak, Goutam Stuart, James M. Cleary, Paul

Published in European Journal of Epidemiology

Successful investigation of national outbreaks of communicable disease relies on rapid identification of the source. Case–control methodologies are commonly used to achieve this. We assessed control selection methods used in recently published case–control studies for methodological and resource issues to determine if a standard approach could be i...

The Genome 10K Project: a way forward.

Koepfli, Klaus-Peter Paten, Benedict O'Brien, Stephen J

Published in Annual review of animal biosciences

The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species. Since then the number of selected and initiated species has risen from ∼26 to 277 sequenced or ongoing with funding, an approximately tenfold in...

Costs of repair of abdominal aortic aneurysm with different devices in a multicenter randomized trial.

Matsumura, Jon S Stroupe, Kevin T Lederle, Frank A Kyriakides, Tassos C Ge, Ling Freischlag, Julie A

Published in Journal of vascular surgery

The implant costs of endovascular aneurysm repair are substantial. When evaluating total health care system expenditures, there is large individual variability in costs, and there is no significant difference at 2 years among systems or when an individual system is compared with open repair.

Comparative genomics reveals insights into avian genome evolution and adaptation.

Zhang, Guojie Li, Cai Li, Qiye Li, Bo Larkin, Denis M Lee, Chul Storz, Jay F Antunes, Agostinho Greenwold, Matthew J Meredith, Robert W ...

Published in Science (New York, N.Y.)

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific...

Whole-genome analyses resolve early branches in the tree of life of modern birds.

Jarvis, Erich D Mirarab, Siavash Aberer, Andre J Li, Bo Houde, Peter Li, Cai Ho, Simon Y W Faircloth, Brant C Nabholz, Benoit Howard, Jason T ...

Published in Science (New York, N.Y.)

To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergen...

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