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Luminal cells are favored as the cell of origin for prostate cancer. PDF available through Get Fulltext Research

Wang, Zhu A Toivanen, Roxanne Bergren, Sarah K Chambon, Pierre Shen, Michael M

Published in Cell reports

The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or luminal epithelial cells, or both, represent cells of origin under physiological conditions in vivo. ...

SLIT/ROBO2 signaling promotes mammary stem cell senescence by inhibiting Wnt signaling. PDF available through Get Fulltext Research

Harburg, Gwyndolen Compton, Jennifer Liu, Wei Iwai, Naomi Zada, Shahrzad Marlow, Rebecca Strickland, Phyllis Zeng, Yi Arial Hinck, Lindsay

Published in Stem cell reports

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negatively regulate WNT signaling. The absence of SLIT/...

Comparative analysis of metazoan chromatin organization. PDF available through Get Fulltext Research

Ho, Joshua W K Jung, Youngsook L Liu, Tao Alver, Burak H Lee, Soohyun Ikegami, Kohta Sohn, Kyung-Ah Minoda, Aki Tolstorukov, Michael Y Appert, Alex ...

Published in Nature

Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation...

Comparative assembly hubs: web-accessible browsers for comparative genomics.

N, Nguyen G, Hickey Bj, Raney J, Armstrong H, Clawson A, Zweig D, Karolchik Wj, Kent David Haussler B, Paten ...

Published in Bioinformatics

Motivation: Researchers now have access to large volumes of genome sequences for comparative analysis, some generated by the plethora of public sequencing projects and, increasingly, from individual efforts. It is not possible, or necessarily desirable, that the public genome browsers attempt to curate all these data. Instead, a wealth of powerful ...

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Flach, Johanna Bakker, Sietske T Mohrin, Mary Conroy, Pauline C Pietras, Eric M Reynaud, Damien Alvarez, Silvia Diolaiti, Morgan E Ugarte, Fernando Forsberg, E Camilla ...

Published in Nature

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age. Paradoxically, although HSCs numerically expand with age, their functional activity declines over time, resulting in degraded blood production and impaired engraftment following transplantation. While many drivers of HSC ageing have ...

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. PDF available through Get Fulltext Research

Hoadley, Katherine A Yau, Christina Wolf, Denise M Cherniack, Andrew D Tamborero, David Ng, Sam Leiserson, Max D M Niu, Beifang McLellan, Michael D Uzunangelov, Vladislav ...

Published in Cell

Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a u...

The mutagenic footprint of low-fidelity Pol I ColE1 plasmid replication in E. coli reveals an extensive interplay betwee...

Troll, Christopher Yoder, Jordan Alexander, David Hernández, Jaime Loh, Yueling Camps, Manel

Published in Current Genetics

ColE1 plasmid replication is unidirectional and requires two DNA polymerases: DNA polymerase I (Pol I) and DNA polymerase III (Pol III). Pol I initiates leading-strand synthesis by extending an RNA primer, allowing the Pol III holoenzyme to assemble and finish replication of both strands. The goal of the present work is to study the interplay betwe...

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model ... PDF available through Get Fulltext Research

Raboune, Siham Stuart, Jordyn M. Leishman, Emma Takacs, Sara M. Rhodes, Brandon Basnet, Arjun Jameyfield, Evan McHugh, Douglas Widlanski, Theodore Bradshaw, Heather B. ...

Published in Frontiers in Cellular Neuroscience

A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-arachidonoyl ethanolamine (Anandamide), and called N-acyl amides have emerged as a family of biologically active compounds at TRP receptors. N-acyl amides are constructed from an acyl group and an amine via an amide bond. This same structure can be modified by ch...

Comprehensive molecular profiling of lung adenocarcinoma. PDF available through Get Fulltext Research

Published in Nature

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen gene...

Assessing the clinical utility of cancer genomic and proteomic data across tumor types. PDF available through Get Fulltext Research

Yuan, Yuan Van Allen, Eliezer M Omberg, Larsson Wagle, Nikhil Amin-Mansour, Ali Sokolov, Artem Byers, Lauren A Xu, Yanxun Hess, Kenneth R Diao, Lixia ...

Published in Nature biotechnology

Molecular profiling of tumors promises to advance the clinical management of cancer, but the benefits of integrating molecular data with traditional clinical variables have not been systematically studied. Here we retrospectively predict patient survival using diverse molecular data (somatic copy-number alteration, DNA methylation and mRNA, microRN...

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