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Theranostic immunoliposomes for osteoarthritis

Cho, Hongsik Stuart, John M. Magid, Richard Danila, Delia C. Hunsaker, Tamra Pinkhassik, Eugene Hasty, Karen A.

Published in Nanomedicine: Nanotechnology, Biology, and Medicine

Schematic diagram of antibody targeted immunoliposomes binding onto damaged cartilage. Antibodies to type II collagen are normally blocked from binding to the surface of the articular cartilage. Proteolytic enzymes secreted by resident chondrocytes, synoviocytes or infiltrating leukocytes degrade the surface proteins and allow access of the antibod...

Effect of fluorosis on liver cells of VC deficient and wild type mice.

Wei, Wei Jiao, Yan Ma, Yonghui Stuart, John M Li, Xiudian Zhao, Fusheng Wang, Lishi Sun, Dianjun Gu, Weikuan

Published in TheScientificWorldJournal

For decades, mouse and other rodents have been used for the study of oxidative or related studies such as the effect of fluoride. It is known that rodents normally synthesize their own vitamin C (VC) due to the presence of a key enzyme in ascorbic acid synthesis, l-gulono-lactone-γ-oxidase (Gulo), while humans do not have the capacity of VC synthes...

Large-scale cytological profiling for functional analysis of bioactive compounds.

Woehrmann, Marcos H Bray, Walter M Durbin, James K Nisam, Sean C Michael, Alicia K Glassey, Emerson Stuart, Joshua M Lokey, R Scott

Published in Molecular bioSystems

Cytological profiling (CP) is an unbiased image-based screening technique that uses automated microscopy and image analysis to profile compounds based on numerous quantifiable phenotypic features. We used CP to evaluate a library of nearly 500 compounds with documented mechanisms of action (MOAs) spanning a wide range of biological pathways. We dev...

Integrative annotation of variants from 1092 humans: application to cancer genomics.

Khurana, Ekta Fu, Yao Colonna, Vincenza Mu, Xinmeng Jasmine Kang, Hyun Min Lappalainen, Tuuli Sboner, Andrea Lochovsky, Lucas Chen, Jieming Harmanci, Arif ...

Published in Science (New York, N.Y.)

Interpreting variants, especially noncoding ones, in the increasing number of personal genomes is challenging. We used patterns of polymorphisms in functionally annotated regions in 1092 humans to identify deleterious variants; then we experimentally validated candidates. We analyzed both coding and noncoding regions, with the former corroborating ...

The Cancer Genome Atlas Pan-Cancer analysis project.

Weinstein, John N Collisson, Eric A Mills, Gordon B Shaw, Kenna R Mills Ozenberger, Brad A Ellrott, Kyle Shmulevich, Ilya Sander, Chris Stuart, Joshua M

Published in Nature genetics

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pa...

Integrated genomic characterization of endometrial carcinoma

Kandoth, Cyriac Schultz, Nikolaus Cherniack, Andrew D. Akbani, Rehan Liu, Yuexin Shen, Hui Gordon Robertson, A. Pashtan, Itai Shen, Ronglai Benz, Christopher C. ...

Published in Nature

This paper from The Cancer Genome Atlas Research Network presents an in-depth genome-wide analysis of endometrial (uterine) carcinomas from more than 350 patients. Based on a series of genomic features including newly identified hotspot mutations in the DNA polymerase gene POLE, and novel mutations in the ARID5B DNA-binding protein, the authors pro...

Retrotransposition of gene transcripts leads to structural variation in mammalian genomes

Ewing, Adam D Ballinger, Tracy J Earl, Dent Harris, Christopher C Ding, Li Wilson, Richard K Haussler, David

Published in Genome Biology

BackgroundRetroposed processed gene transcripts are an important source of material for new gene formation on evolutionary timescales. Most prior work on gene retrocopy discovery compared copies in reference genome assemblies to their source genes. Here, we explore gene retrocopy insertion polymorphisms (GRIPs) that are present in the germlines of ...

Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for p...

Wang, Zhu A Mitrofanova, Antonina Bergren, Sarah K Abate-Shen, Cory Cardiff, Robert D Califano, Andrea Shen, Michael M

Published in Nature cell biology

A key issue in cancer biology is whether oncogenic transformation of different cell types of origin within an adult tissue gives rise to distinct tumour subtypes that differ in their prognosis and/or treatment response. We now show that initiation of prostate tumours in basal or luminal epithelial cells in mouse models results in tumours with disti...

Brain levels of prostaglandins, endocannabinoids, and related lipids are affected by mating strategies.

Stuart, Jordyn M Paris, Jason J Frye, Cheryl Bradshaw, Heather B

Published in International journal of endocrinology

Background. Endogenous cannabinoids (eCBs) are involved in the development and regulation of reproductive behaviors. Likewise, prostaglandins (PGs) drive sexual differentiation and initiation of ovulation. Here, we use lipidomics strategies to test the hypotheses that mating immediately activates the biosynthesis and/or metabolism of eCBs and PGs a...

Methods for identifying Neisseria meningitidis carriers: a multi-center study in the African meningitis belt.

Basta, Nicole E Stuart, James M Nascimento, Maria C Manigart, Olivier Trotter, Caroline Hassan-King, Musa Chandramohan, Daniel Sow, Samba O Berthe, Abdoulaye Bedru, Ahmed ...

Published in PloS one

Detection of meningococcal carriers is key to understanding the epidemiology of Neisseria meningitidis, yet no gold standard has been established. Here, we directly compare two methods for collecting pharyngeal swabs to identify meningococcal carriers. We conducted cross-sectional surveys of schoolchildren at multiple sites in Africa to compare swa...

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