Kimata, Masaru Cullins, David L Brown, Monica L Brand, David D Rosloniec, Edward F Myers, Linda K Stuart, John M Kang, Andrew H
Published in
Arthritis Research & Therapy
Introduction We used DR1 transgenic mice and covalently linked DR1 multimers to characterize analog-specific inhibitory T cells in collagen-induced arthritis (CIA). Because of the low numbers of antigen-specific T cells in wild-type mice, functional T-cell studies in autoimmune arthritis have been challenging. The use of T-cell receptor (TCR) trans...
Tang, Bo Cullins, David L Zhou, Jing Zawaski, Janice A Park, Hyelee Brand, David D Hasty, Karen A Gaber, M Waleed Stuart, John M Kang, Andrew H
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Published in
Arthritis Research & Therapy
IntroductionRheumatoid arthritis (RA) is a systemic disease manifested by chronic inflammation in multiple articular joints, including the knees and small joints of the hands and feet. We have developed a unique modification to a clinically accepted method for delivering therapies directly to the synovium. Our therapy is based on our previous disco...
Sakurai, Y Brand, Dd Tang, B Rosloniec, Ef Josh Stuart Kang, Ah Myers, Lk
Published in
Arthritis Research & Therapy
Rheumatoid arthritis (RA) is an autoimmune disease associated with the recognition of self proteins secluded in diarthrodial joints. We have previously established that mice transgenic for the human DR genes associated with RA are susceptible to collagen-induced arthritis (CIA) and we have identified a determinant of type II collagen (CII(263-270))...
Tang, Bo Kim, Seunghyun Hammond, Sarah Cullins, David L Brand, David D Rosloniec, Edward F Stuart, John M Postlethwaite, Arnold E Kang, Andrew H Myers, Linda K
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Published in
Arthritis Research & Therapy
IntroductionT cells orchestrate joint inflammation in rheumatoid arthritis (RA), yet they are difficult to study due to the small numbers of antigen-specific cells. The goal of this study was to characterize a new humanized model of autoimmune arthritis and to describe the phenotypic and functional changes that occur in autoimmune T cells following...
