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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. PDF available through Get Fulltext Research

Lee, John K Phillips, John W Smith, Bryan A Park, Jung Wook Stoyanova, Tanya McCaffrey, Erin F Baertsch, Robert Sokolov, Artem Meyerowitz, Justin G Mathis, Colleen ...

Published in Cancer cell

MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostat...

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