Hashimoto, Daigo Chow, Andrew Noizat, Clara Teo, Pearline Beasley, Mary Beth Leboeuf, Marylene Becker, Christian D See, Peter Price, Jeremy Lucas, Daniel
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Published in
Immunity
Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis and fate-mapping approaches, we confirmed that monocytes do not show significant contribution to tissue macrophages in the steady state. Similarly, we found that...
Epelman, S Lavine, Kj Beaudin, Ae Sojka, Dk Carrero, Ja Calderon, B Brija, T Gautier, El Ivanov, S Satpathy, At
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Published in
Immunity
Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6c(hi) monocytes contribut...
