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Pathway-Based Genomics Prediction using Generalized Elastic Net. PDF available through Get Fulltext Research

Sokolov, Artem Carlin, Daniel E Paull, Evan O Baertsch, Robert Stuart, Joshua M

Published in PLoS computational biology

We present a novel regularization scheme called The Generalized Elastic Net (GELnet) that incorporates gene pathway information into feature selection. The proposed formulation is applicable to a wide variety of problems in which the interpretation of predictive features using known molecular interactions is desired. The method naturally steers sol...

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