Gaydos, Laura J Wang, Wenchao Strome, Susan
Published in
Science (New York, N.Y.)
For proper development, cells must retain patterns of gene expression and repression through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but its transmission is not well understood. Our studies suggest that PRC2 represses the X chromosomes in Caenorhabditis elegans...
Susan Strome Lehmann, R
Published in
Science
The early embryo is formed by the fusion of two germ cells that must generate not only all of the nonreproductive somatic cell types of its body but also the germ cells for the next generation. Therefore, embryo cells face a crucial decision: whether to develop as germ or soma. How is this fundamental decision made and germ cell fate maintained dur...
Zhang, Guojie Li, Cai Li, Qiye Li, Bo Larkin, Denis M Lee, Chul Storz, Jay F Antunes, Agostinho Greenwold, Matthew J Meredith, Robert W
...
Published in
Science (New York, N.Y.)
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific...
Lowe, Craig B Kellis, Manolis Siepel, Adam Raney, Brian J Clamp, Michele Salama, Sofie R Kingsley, David M Lindblad-Toh, Kerstin Haussler, David
Published in
Science (New York, N.Y.)
The gain, loss, and modification of gene regulatory elements may underlie a substantial proportion of phenotypic changes on animal lineages. To investigate the gain of regulatory elements throughout vertebrate evolution, we identified genome-wide sets of putative regulatory regions for five vertebrates, including humans. These putative regulatory r...
Jarvis, Erich D Mirarab, Siavash Aberer, Andre J Li, Bo Houde, Peter Li, Cai Ho, Simon Y W Faircloth, Brant C Nabholz, Benoit Howard, Jason T
...
Published in
Science (New York, N.Y.)
To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergen...
Rocchi, M Schein, Je Baertsch, R Clarke, L Csürös, M Glasscock, J Harris, Ra Havlak, P Jackson, Ar Jiang, H
...
Published in
Science
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an...
Katzman, S Kern, Ad Bejerano, G Fewell, G Fulton, L Wilson, Rk Salama, Sr David Haussler
Published in
Science
Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for t...
Brumbaugh, Pf David Haussler Bressler, R Haussler, Mr
Published in
Science
A competitive protein binding assay with a sensitivity of 80 picograms has been developed for 1alpha,25-dihydroxyvitamin D(3), the hormonal form of vitamin D(3). lalpha,25-Dihydroxyvitamin D(3) displaced tritiated hormone from a cytosol-chromatin receptor preparation isolated from chick small intestine, providing a simple assay for the hormone. The...
Yoo, Tj Josh Stuart Kang, Ah Townes, As Tomoda, K Dixit, S
Published in
Science
Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere s disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations sugges...
Global Alliance For Genomics And, Health...
Published in
Science
